A Key Role for Diacylglycerol Lipase-α in Metabotropic Glutamate Receptor-Dependent Endocannabinoid Mobilization

  title={A Key Role for Diacylglycerol Lipase-$\alpha$ in Metabotropic Glutamate Receptor-Dependent Endocannabinoid Mobilization},
  author={Kwang-Mook Jung and Giuseppe Astarita and Chenggang Zhu and Matthew Wallace and Ken Mackie and Daniele Piomelli},
  journal={Molecular Pharmacology},
  pages={612 - 621}
Activation of group I metabotropic glutamate (mGlu) receptors recruits the endocannabinoid system to produce both short- and long-term changes in synaptic strength in many regions of the brain. Although there is evidence that the endocannabinoid 2-arachidonoylglycerol (2-AG) mediates this process, the molecular mechanism underlying 2-AG mobilization remains unclear. In the present study, we used a combination of genetic and targeted lipidomic approaches to investigate the role of the… 

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