A KATP channel gene effect on sleep duration: from genome-wide association studies to function in Drosophila

  title={A KATP channel gene effect on sleep duration: from genome-wide association studies to function in Drosophila},
  author={Karla Viviani Allebrandt and Najaf Amin and Bertram M{\"u}ller-Myhsok and T{\"o}nu Esko and Maris Teder-Laving and Renata V. D. M. Azevedo and Caroline Hayward and Josine G. van Mill and Nicole Vogelzangs and Edward W. Green and Scott A. Melville and Peter Lichtner and H Wichmann and Ben A. Oostra and A Cecile J W Janssens and Harry Campbell and James F Wilson and Andrew A Hicks and Peter P. Pramstaller and Zoran Dogas and Igor Rudan and Martha Merrow and B W J H Penninx and Charalambos P Kyriacou and Andres Metspalu and Cornelia M. van Duijn and Thomas Meitinger and Till Roenneberg},
  journal={Molecular Psychiatry},
Humans sleep approximately a third of their lifetime. The observation that individuals with either long or short sleep duration show associations with metabolic syndrome and psychiatric disorders suggests that the length of sleep is adaptive. Although sleep duration can be influenced by photoperiod (season) and phase of entrainment (chronotype), human familial sleep disorders indicate that there is a strong genetic modulation of sleep. Therefore, we conducted high-density genome-wide… CONTINUE READING
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