A K cation-induced conformational switch within a loop spanning segment of a DNA quadruplex containing G-G-G-C repeats.

@article{Bouaziz1998AKC,
  title={A K cation-induced conformational switch within a loop spanning segment of a DNA quadruplex containing G-G-G-C repeats.},
  author={Serge Bouaziz and Abdelali Kettani and Dinshaw J. Patel},
  journal={Journal of molecular biology},
  year={1998},
  volume={282 3},
  pages={637-52}
}
We have identified a unique structural transition (in slow exchange on the NMR time scale) in the tertiary fold of the d(G-G-G-C-T4-G-G-G-C) quadruplex on proceeding from Na+ to K+ as counterion in aqueous solution. Both monovalent cation-dependent conformations exhibit certain common structural features, which include head-to-tail dimerization of two symmetry-related stem-hairpin loops, adjacent strands which are antiparallel to each other and adjacent stacked G(syn).G(anti). G(syn).G(anti… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 21 extracted citations

Similar Papers

Loading similar papers…