A Janus kinase inhibitor, JAB, is an interferon-gamma-inducible gene and confers resistance to interferons.

@article{Sakamoto1998AJK,
  title={A Janus kinase inhibitor, JAB, is an interferon-gamma-inducible gene and confers resistance to interferons.},
  author={Hiroshi Sakamoto and Hideo Yasukawa and Masaaki Masuhara and Shyu Tanimura and Atsuo T. Sasaki and Kentaro Yuge and Motoaki Ohtsubo and Akira Ohtsuka and Takasi Fujita and Tsunetaka Ohta and Yusuke Furukawa and Satsuki Iwase and Hisashi Yamada and Akihiko Yoshimura},
  journal={Blood},
  year={1998},
  volume={92 5},
  pages={1668-76}
}
It has been shown that interferons (IFNs) exert their signals through receptor-associated Janus kinases (JAKs) and signal transducers and activators of transcription (STATs). However, molecular mechanism of regulation of IFN signaling has not been fully understood. We have reported novel cytokine-inducible SH2 protein (CIS) and JAK binding protein (JAB) family genes that can potentially modulate cytokine signaling. Here we report that JAB is strongly induced by IFN-gamma but not by IFN-beta in… CONTINUE READING

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