A Hypnic Hypothesis of Alzheimer's Disease

@article{Clark2013AHH,
  title={A Hypnic Hypothesis of Alzheimer's Disease},
  author={Camilla N. Clark and Jason D. Warren},
  journal={Neuro-Degenerative Diseases},
  year={2013},
  volume={12},
  pages={165 - 176}
}
  • C. Clark, J. Warren
  • Published 26 April 2013
  • Biology, Psychology
  • Neuro-Degenerative Diseases
Background: Understanding the pathophysiology of Alzheimer's disease (AD) is of fundamental importance for improved diagnosis, monitoring and ultimately, treatment. Objective: A role for the sleep-wake cycle in the pathogenesis of AD has been proposed, but remains to be worked out in detail. Methods: Here we draw together several lines of previous work to outline a ‘hypnic hypothesis' of AD. Results: We propose that altered function of brainstem neurotransmitter pathways associated with sleep… 
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