A Hypnic Hypothesis of Alzheimer's Disease

@article{Clark2013AHH,
  title={A Hypnic Hypothesis of Alzheimer's Disease},
  author={Camilla N. Clark and Jason D. Warren},
  journal={Neuro-Degenerative Diseases},
  year={2013},
  volume={12},
  pages={165 - 176}
}
  • C. Clark, J. Warren
  • Published 26 April 2013
  • Biology, Psychology
  • Neuro-Degenerative Diseases
Background: Understanding the pathophysiology of Alzheimer's disease (AD) is of fundamental importance for improved diagnosis, monitoring and ultimately, treatment. Objective: A role for the sleep-wake cycle in the pathogenesis of AD has been proposed, but remains to be worked out in detail. Methods: Here we draw together several lines of previous work to outline a ‘hypnic hypothesis' of AD. Results: We propose that altered function of brainstem neurotransmitter pathways associated with sleep… 
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Evaluating the current evidence on the role of sleep deprivation in Aβ clearance metabolism discusses possible mechanisms underlying the bidirectional interaction between the sleep deprivation and A β clearance pathways.
Aberrant brain stem morphometry associated with sleep disturbance in drug-naïve subjects with Alzheimer’s disease
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This study is the first to analyze an association between sleep disturbances and brain stem morphology in AD and lends support to the possibility that brain stem structural abnormalities might be important neurobiological mechanisms underlying sleep disturbances associated with AD.
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NDDs, are wrongly classified as neurodegenerative disorders because they are of ischemic origin caused by cerebral atherosclerosis, associated with vascular anomalies and/or envi- ronmental chemicals.
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The literature of sleep, aging, cognition, and the impact of two common clinical conditions (obstructive sleep apnea and insomnia) on cognitive impairment is reviewed to integrate the separate mechanisms towards more generalized common pathways.

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