A Hybrid Model of Mammalian Cell Cycle Regulation

  title={A Hybrid Model of Mammalian Cell Cycle Regulation},
  author={Rajat Singhania and R. Michael Sramkoski and James W. Jacobberger and John J. Tyson},
  booktitle={PLoS Computational Biology},
The timing of DNA synthesis, mitosis and cell division is regulated by a complex network of biochemical reactions that control the activities of a family of cyclin-dependent kinases. The temporal dynamics of this reaction network is typically modeled by nonlinear differential equations describing the rates of the component reactions. This approach provides exquisite details about molecular regulatory processes but is hampered by the need to estimate realistic values for the many kinetic… CONTINUE READING


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The yeast cell-cycle network is robustly designed.

Proceedings of the National Academy of Sciences of the United States of America • 2004
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The Biology of the Cell Cycle

JM Mitchison
View 5 Excerpts
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Simulation of Dynamic Systems with Matlab and Simulink by Klee Harold

J. Artificial Societies and Social Simulation • 2008
View 1 Excerpt

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