A Humanized Version of Foxp2 Affects Cortico-Basal Ganglia Circuits in Mice

  title={A Humanized Version of Foxp2 Affects Cortico-Basal Ganglia Circuits in Mice},
  author={Wolfgang Enard and Sabine Gehre and Kurt Hammerschmidt and Sabine M H{\"o}lter and Torsten Blass and Mehmet Somel and Martina K. Br{\"u}ckner and Christiane Schreiweis and Christine Winter and Reinhard Sohr and Lore Becker and Victor Wiebe and Birgit Nickel and Thomas Giger and Uwe M{\"u}ller and Matthias Groszer and Thure Adler and Antonio Aguilar and Ines Bolle and Julia Calzada-Wack and Claudia Dalke and Nicole Ehrhardt and Jack Favor and Helmut Fuchs and Val{\'e}rie Gailus-Durner and Wolfgang Hans and Gabriele Hoelzlwimmer and Anahita Javaheri and S vetoslav Kalaydjiev and Magdalena Kallnik and Eva Kling and Sandra Kunder and Ilona Mossbrugger and Beatrix Naton and Ildiko Racz and Birgit Rathkolb and Jan Rozman and Anja Schrewe and Dirk H Busch and Jochen Graw and Boris Ivandic and Martin Klingenspor and Thomas Klopstock and Markus W. Ollert and Leticia Quintanilla-Martinez and Holger Schulz and Eckhard Wolf and Wolfgang Wurst and Andreas Zimmer and Simon E. Fisher and Rudolf Morgenstern and Thomas Arendt and Martin Hrab{\'e} de Angelis and Julia Fischer and Johannes Schwarz and Svante P{\"a}{\"a}bo},
It has been proposed that two amino acid substitutions in the transcription factor FOXP2 have been positively selected during human evolution due to effects on aspects of speech and language. Here, we introduce these substitutions into the endogenous Foxp2 gene of mice. Although these mice are generally healthy, they have qualitatively different ultrasonic vocalizations, decreased exploratory behavior and decreased dopamine concentrations in the brain suggesting that the humanized Foxp2 allele… CONTINUE READING
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