A Human Protein Interaction Network Shows Conservation of Aging Processes between Human and Invertebrate Species

@article{Bell2009AHP,
  title={A Human Protein Interaction Network Shows Conservation of Aging Processes between Human and Invertebrate Species},
  author={Russell Bell and Alan Hubbard and Rakesh Chettier and Di Chen and John P Miller and Pankaj Kapahi and Mark A Tarnopolsky and Sudhir Sahasrabuhde and Simon Melov and Robert E. Hughes},
  journal={PLoS Genetics},
  year={2009},
  volume={5},
  pages={288 - 290}
}
We have mapped a protein interaction network of human homologs of proteins that modify longevity in invertebrate species. This network is derived from a proteome-scale human protein interaction Core Network generated through unbiased high-throughput yeast two-hybrid searches. The longevity network is composed of 175 human homologs of proteins known to confer increased longevity through loss of function in yeast, nematode, or fly, and 2,163 additional human proteins that interact with these… CONTINUE READING