A Human Protein Complex Homologous to the Drosophila MSL Complex Is Responsible for the Majority of Histone H4 Acetylation at Lysine 16

@article{Smith2005AHP,
  title={A Human Protein Complex Homologous to the Drosophila MSL Complex Is Responsible for the Majority of Histone H4 Acetylation at Lysine 16},
  author={Edwin R. Smith and Christelle Cayrou and R. Huang and William Arbuthnot Sir Lane and J. C{\^o}t{\'e} and J. Lucchesi},
  journal={Molecular and Cellular Biology},
  year={2005},
  volume={25},
  pages={9175 - 9188}
}
ABSTRACT We describe a stable, multisubunit human histone acetyltransferase complex (hMSL) that contains homologs of the Drosophila dosage compensation proteins MOF, MSL1, MSL2, and MSL3. This complex shows strong specificity for histone H4 lysine 16 in chromatin in vitro, and RNA interference-mediated knockdown experiments reveal that it is responsible for the majority of H4 acetylation at lysine 16 in the cell. We also find that hMOF is a component of additional complexes, forming… Expand
Genome-wide distribution of histone H4 Lysine 16 acetylation sites and their relationship to gene expression
The Functional Analysis of Histone Acetyltransferase MOF in Tumorigenesis
Males absent on the first (MOF): from flies to humans
Dynamics of H4 K16 acetylation by the SAS-I complex in Saccharomyces cerevisiae
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 74 REFERENCES
The Drosophila MSL Complex Acetylates Histone H4 at Lysine 16, a Chromatin Modification Linked to Dosage Compensation
The Yeast NuA4 and Drosophila MSL Complexes Contain Homologous Subunits Important for Transcription Regulation*
Structural and Functional Conservation of the NuA4 Histone Acetyltransferase Complex from Yeast to Humans
Linking Global Histone Acetylation to the Transcription Enhancement of X-chromosomal Genes in Drosophila Males*
A Novel H2A/H4 Nucleosomal Histone Acetyltransferase in Tetrahymena thermophila
Modulation of ISWI function by site‐specific histone acetylation
Acetylated histone H4 on the male X chromosome is associated with dosage compensation in Drosophila.
...
1
2
3
4
5
...