A Human Genome Diversity Cell Line Panel

  title={A Human Genome Diversity Cell Line Panel},
  author={Howard M. Cann and Claudia de Toma and Lucien Cazes and M F Legrand and Valerie Morel and Laurence Piouffre and Julia G. Bodmer and Walter F. Bodmer and Batsheva Bonn{\'e}‐Tamir and Anne Cambon-Thomsen and Zhu Chen and Jiayou Chu and Carlo Carcassi and Licinio Contu and Ruofu Du and Laurent Excoffier and Giovanni Battista Ferrara and Jonathan Scott Friedlaender and Helena Groot and David Gurwitz and Trefor Jenkins and Rene J Herrera and Xiaoyi Huang and Judith R. Kidd and Kenneth K. Kidd and Andr{\'e} Langaney and Alice A. Lin and Syed Qasim Mehdi and Peter Parham and Alberto Piazza and Maria Pia Pistillo and Ya-ping Qian and Qunfang Shu and Jiujin Xu and S. Zhu and James L. Weber and Henry T. Greely and Marcus W. Feldman and Gilles D. Thomas and Jean B. Dausset and Luigi Luca Cavalli-Sforza},
  pages={261 - 262}
A resource of 1064 cultured lymphoblastoid cell lines (LCLs) ([1][1]) from individuals in different world populations and corresponding milligram quantities of DNA is deposited at the Foundation Jean Dausset (CEPH) ([2][2]) in Paris. LCLs were collected from various laboratories by the Human Genome 
Genetic instability in EBV-transformed lymphoblastoid cell lines.
Standardized Subsets of the HGDP‐CEPH Human Genome Diversity Cell Line Panel, Accounting for Atypical and Duplicated Samples and Pairs of Close Relatives
Pairs of close relatives that have been included in the HGDP‐CEPH Human Genome Diversity Cell Line Panel are identified and inferred relative pairs suggest standardized subsets of the panel for use in future population‐genetic studies.
Cell Culture Models of Genetic Variation
It is found that lymphoblastoid cell lines are a reliable experimental platform that can be used for consistently repeatable phenotyping, providing that sensible approaches to cell culture, experiment design, and data processing are adopted.
Human Genome Diversity Project (HGDP)
The Human Genome Diversity Project was proposed as a public project to collect and analyze DNA samples from diverse human populations, but while never realized, the investigation of human genetic variation largely has been taken over by more biomedically oriented initiatives.
Genome-wide transcriptomic variations of human lymphoblastoid cell lines: insights from pairwise gene-expression correlations.
Probing genome-wide transcriptomic data sets of LCLs from unrelated individuals may detect coregulated genes, adding insights on cellular regulation by miRNAs.
In Vitro Whole-Genome Analysis Identifies a Susceptibility Locus for HIV-1
An in vitro system is used for the identification of a locus on HSA8q24.3 associated with cellular susceptibility to HIV-1 and a role of the rs2572886 region in the regulation of the LY6 family of glycosyl-phosphatidyl-inositol (GPI)-anchored proteins is suggested.
The Origin and Evolution of Variable Number Tandem Repeat of CLEC4M Gene in the Global Human Population
It is implied that most of the VNTR alleles existed before dispersion of modern humans outside Africa, and the present diversity profile of this locus in worldwide populations is generated from the effect of migration of different tribes and neutral evolution.
Collection and storage of human blood cells for mRNA expression profiling: a 15-month stability study.
A quality-assured and controlled protocol of PBMC banking for further mRNA expression analysis is proposed and a comparison of the concentration, purity, integrity, and stability of the total RNA is compared.
LINE-1 Retrotransposition Activity in Human Genomes


Culture of immortalized cells
Partial table of contents: Human Keratinocyte Immortalization: Genetic Basis and Role in Squamous Cell Carcinoma Development (E. Parkinson). Safety Procedures (J. Caputo). Mapping Human Senescence
Advances in PCR-based detection of mycoplasmas contaminating cell cultures.
M ycoplasmas (the trivial name for microorganisms belonging to the class Mollicutes) are the smallest free-living, self-replicating bacteria, having diameters of 300 to 800 nm. These pleomorph
Y chromosome sequence variation and the history of human populations
Binary polymorphisms associated with the non-recombining region of the human Y chromosome (NRY) preserve the paternal genetic legacy of our species that has persisted to the present, permitting
An apportionment of human DNA diversity.
By partitioning genetic variances at three hierarchical levels of population subdivision, it is found that differences between members of the same population account for 84.4% of the total, which is in excellent agreement with estimates based on allele frequencies of classic, protein polymorphisms.
Comprehensive human genetic maps: individual and sex-specific variation in recombination.
Comprehensive human genetic maps were constructed on the basis of nearly 1 million genotypes from eight CEPH families; they incorporated >8,000 short tandem-repeat polymorphisms (STRPs), primarily
The genetic legacy of Paleolithic Homo sapiens sapiens in extant Europeans: a Y chromosome perspective.
A significant correlation between the NRY haplotype data and principal components based on 95 protein markers was observed, indicating the effectiveness of NRY binary polymorphisms in the characterization of human population composition and history.
Statistical properties of the variation at linked microsatellite loci: implications for the history of human Y chromosomes.
It is suggested that a sweep or extreme bottleneck is unlikely to have occurred anytime during the last approximately 74,000 years, and in order to reject mutation-drift equilibrium at a set of linked microsatellite loci it is necessary to have an unreasonably large number of loci unless the observed variance is far below that expected at mutation- drift equilibrium.
The Human Revolution: Behavioural and Biological Perspectives on the Origins of Modern Humans
No other work provides such an exhaustive and wide-ranging account of modern human origins on a world-wide scale and is the only book which integrates the remarkable new genetic evidence with the more conventional approaches of archaeologists and anthropologists.