A Hox Regulatory Network Establishes Motor Neuron Pool Identity and Target-Muscle Connectivity

@article{Dasen2005AHR,
  title={A Hox Regulatory Network Establishes Motor Neuron Pool Identity and Target-Muscle Connectivity},
  author={Jeremy S Dasen and Bonnie C. Tice and Susan Brenner-Morton and Thomas M. Jessell},
  journal={Cell},
  year={2005},
  volume={123},
  pages={477-491}
}
Spinal motor neurons acquire specialized "pool" identities that determine their ability to form selective connections with target muscles in the limb, but the molecular basis of this striking example of neuronal specificity has remained unclear. We show here that a Hox transcriptional regulatory network specifies motor neuron pool identity and connectivity. Two interdependent sets of Hox regulatory interactions operate within motor neurons, one assigning rostrocaudal motor pool position and a… CONTINUE READING