• Corpus ID: 54871505

A Holistic Review on Ethosome: A Promising Drug Delivery System for Topical Fungal Disease

@article{Dhurve2014AHR,
  title={A Holistic Review on Ethosome: A Promising Drug Delivery System for Topical Fungal Disease},
  author={Roshni Dhurve},
  journal={International Journal of Pharmaceutical \& Biological Archive},
  year={2014},
  volume={5}
}

• R. Dhurve
• Published 2014
• Biology
• International Journal of Pharmaceutical & Biological Archive

Topical drug delivery system has been used widely for various kinds of topical diseases. Topical therapy is good choice for the treatment of the cutaneous infections due to its advantages such as targeting of drugs to the site of infection and reduction of the risk of systemic side effects. Fungal infections of the skin are one of the often faced dermatological diseases in worldwide. The earlier approaches that has been used to treat these diseases such as creams, ointment or jellies are not efficient in treatment of these diseases in terms of bioavailability and therapeutic effect, so to overcome this problem ethosomes have been arrived showing best results in the treatment of topical fungal diseases. Ethosomes are lipid vesicles which are soft and flexible. They consist of phospholipid,alcohol(ethanol,isopropyl alcohol),poly glycol(propylene glycol)and water. The most important feature of ethosome is to permeate intact through the skin due to its high deformability and also helps to transport the active substances or drug molecule more efficiently through the skin in terms of both quantity and depth. Ethosomes can provide effective intracellular delivery of hydrophilic, amphiphilic and lipophilic drug molecules. The size range of ethosomes varies from tens of nanometer to few microns. Ethosomal drug delivery system is a new novel tool for drug delivery with safety and efficacy. Ethosomes have become an area of research interest, because of its special characters such as enhanced skin permeation, improved drug delivery and increased drug entrapment efficiency. This review on ethosomes drug delivery is to focus on the various aspects including their mechanism of penetration, preparation, advantages, characterization and composition and the list of antifungal drugs which have been reported by various researchers.