A Holistic Multi Evidence Approach to Study the Fragmentation Behaviour of Crystalline Mannitol

@inproceedings{Koner2015AHM,
  title={A Holistic Multi Evidence Approach to Study the Fragmentation Behaviour of Crystalline Mannitol},
  author={Jasdip S. Koner and Ali R. Rajabi-Siahboomi and James Bowen and Yvonne Perrie and Daniel J Kirby and Afzal R Mohammed},
  booktitle={Scientific reports},
  year={2015}
}
Mannitol is an essential excipient employed in orally disintegrating tablets due to its high palatability. However its fundamental disadvantage is its fragmentation during direct compression, producing mechanically weak tablets. The primary aim of this study was to assess the fracture behaviour of crystalline mannitol in relation to the energy input during direct compression, utilising ball milling as the method of energy input, whilst assessing tablet characteristics of post-milled powders… CONTINUE READING

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References

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Showing 1-10 of 47 references

Mechanical Analysis of the Effects of Different Mechanical Alloying Periods on Ni3Al Intermetallic Compound Fabrication Quality

Tan, K.-H
Int. J. Electrochem. Sci • 2012

Fast disintegrating tablets: Opportunity in drug delivery system

Journal of advanced pharmaceutical technology & research • 2011

Opportunity in drug delivery system

5Parkash, V. et al. Fast disintegrating tablets
J Adv Pharm Technol Res 2, 223–235, doi: 10.4103/2231-4040.90877 • 2011

Orally disintegrating tablets a valuable life cycle management strategy in

T. M. Harmon
J Adv Pharm Technol Res • 2011

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