A History of the Isolation and Identification of Vitamin B6

@article{Rosenberg2012AHO,
  title={A History of the Isolation and Identification of Vitamin B6},
  author={Irwin H. Rosenberg},
  journal={Annals of Nutrition and Metabolism},
  year={2012},
  volume={61},
  pages={236 - 238}
}
  • I. Rosenberg
  • Published 1 November 2012
  • Biology
  • Annals of Nutrition and Metabolism
In the 1930s, Rudolf Peters showed that young rats kept on a semi-synthetic diet with added thiamin and riboflavin but no other supplement developed ‘rat acrodynia’, a condition characterized by severe cutaneous lesions. In 1934, Paul György showed that the factor which cured ‘rat acrodynia’ was vitamin B6. Other studies soon showed that vitamin B6 deficiency produced convulsions in rats, pigs, and dogs, and a microcytic anemia in certain animals. Samuel Lepkovsky isolated and crystallized… 

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References

SHOWING 1-10 OF 27 REFERENCES

The water-soluble B-vitamins other than aneurin (vitamin B(1)), riboflavin and nicotinic acid required by the pig.

The dog, the pig and the monkey appear to resemble more closely the human being in their requirement of nicotinic acid in their food and consequently in their failure to maintain health on diets consisting too largely of maize.

Crystalline Vitamin B-6.∗

Starting with rice bran, the crystalline hydrochloride of a nitrogen base having the properties of Vitamin B-6 is isolated and is freely soluble in water and sparingly in alcohol and acetone.

Vitamin B2 and the Pellagra-like Dermatitis in Rats

The flavin pigment was identified by us with vitamin B2 by its growth-promoting properties and it was a question for further investigation whether in these circumstances it was also identical with the ‘anti-dermatitis factor’ and in particular with the 'pellagra preventing factor'.

Vitamin B6 and Skin Lesions in Rats

Vitamin B61 has been defined2 as “that part of the vitamin B2 complex which is responsible for the cure of the specific dermatitis developed by young rats fed on a vitamin B-free diet supplemented

Synthese des Adermins

En twick lungs s tufe de r europ~tischen Menschhe i t wird sich nach den bisher vor l iegenden F u n d e n wohl n i ch t e infach leugnen lassen.

Effect of Heat Sterilization on Growth-Promoting Activity of Pyridoxine for Streptococcus lactis R

Results cited below show that the conversion results not from activities of the test organism, but rather from interaction of pyridoxine with certain constituents of the trast to those secured with all other known nutrilites which have been investigated.