A History of the Isolation and Identification of Vitamin B6

  title={A History of the Isolation and Identification of Vitamin B6},
  author={Irwin H. Rosenberg},
  journal={Annals of Nutrition and Metabolism},
  pages={236 - 238}
  • I. Rosenberg
  • Published 1 November 2012
  • Chemistry, Medicine
  • Annals of Nutrition and Metabolism
In the 1930s, Rudolf Peters showed that young rats kept on a semi-synthetic diet with added thiamin and riboflavin but no other supplement developed ‘rat acrodynia’, a condition characterized by severe cutaneous lesions. In 1934, Paul György showed that the factor which cured ‘rat acrodynia’ was vitamin B6. Other studies soon showed that vitamin B6 deficiency produced convulsions in rats, pigs, and dogs, and a microcytic anemia in certain animals. Samuel Lepkovsky isolated and crystallized… 
Overexpression of a non-native deoxyxylulose-dependent vitamin B6 pathway in Bacillus subtilis for the production of pyridoxine.
The generation and characterization of a Bacillus subtilis pyridoxine production strain overexpressing five genes of a non-native deoxyxylulose 5'-phosphate-dependent vitamin B6 pathway is described, which provides a promising basis to further enhance the production of pyrIDoxine using B. subtILis.
Vitamin B6 metabolism in microbes and approaches for fermentative production.
Novel routes for vitamin B6 biosynthesis are described and their potential for engineering bacteria that overproduce the commercially valuable substance is discussed and bottlenecks of the vitamin B 6 biosynthetic pathways are highlighted.
Pyridoxine stimulates filaggrin production in human epidermal keratinocytes.
This study is the first to report that PN causes an increase in filaggrin transcription and production, and these results suggest that Pn-induced filag Grin production may be a useful target as a daily care component in atopic dermatitis, wherein filag grin levels are specifically reduced.
Engineering Bacillus subtilis for the conversion of the antimetabolite 4-hydroxy-l-threonine to pyridoxine.
The present study uncovered several enzymes with promiscuous activity and it revealed that host metabolic pathways compete with the heterologous pathway for 4-HO-Thr, and the B. subtilis genome is quite flexible with respect to adaptive mutations, a property, which is very important for strain engineering.
Intracellular trafficking of the pyridoxal cofactor. Implications for health and metabolic disease.
  • J. W. Whittaker
  • Biology, Medicine
    Archives of biochemistry and biophysics
  • 2016
The aim of this review is to concisely summarize the state of current knowledge of intracellular trafficking of PLP and to identify key directions for future research.
The Emerging Role of Vitamin B6 in Inflammation and Carcinogenesis.
  • R. Bird
  • Medicine
    Advances in food and nutrition research
  • 2018
Recent developments in the molecular role of B6 and its direct interaction with inflammasomes, and nuclear receptor corepressor and coactivator, receptor-interacting protein 140, provide a strong impetus to further explore the multifaceted role ofB6 in carcinogenesis and human health.
Underground metabolism facilitates the evolution of novel pathways for vitamin B6 biosynthesis
The potential of the serendipitous pathways to serve as a starting point for the development of bacteria overproducing vitamin B6 is discussed, as underground metabolism facilitates the emergence of novel vitamin B 6 biosynthetic pathways.
Deficiency of Vitamin B-Complex and Its Relation with Body Disorders
  • M. Sarwar, Muhammad Haroon Sarwar, Muhammad Aqeel Sarwar
  • Medicine
    B-Complex Vitamins - Sources, Intakes and Novel Applications [Working Title]
  • 2021
This chapter provides an affluent of the most common types of vitamins B, including why body needs these, their deficiency symptoms and which foods contain them.
Introduction: The Diverse and Essential Biological Functions of Vitamins
One hundred years ago, in 1912, the Polish-American scientist Casimir Funk coined the term ‘vitamine’ to describe a group of bioactive substances the authors now know to be essential for human health – a pivotal discovery that has contributed to a century of innovative research and improved health.
Disorders of vitamins and cofactors
Vitamins and cofactors are essential for the health and development of humans. Most are not synthesized by humans and must be obtained from exogenous sources. They are involved in a number of


The relation between vitamin B6 and the unsaturated fatty acid factor.
The work of Burr, Burr, and Miller (l-3) showed that rats fed on a diet totally devoid of fat suffered from a deficiency disease which was curable by the administration of fats containing highly
The water-soluble B-vitamins other than aneurin (vitamin B(1)), riboflavin and nicotinic acid required by the pig.
The dog, the pig and the monkey appear to resemble more closely the human being in their requirement of nicotinic acid in their food and consequently in their failure to maintain health on diets consisting too largely of maize.
Crystalline Vitamin B-6.∗
Starting with rice bran, the crystalline hydrochloride of a nitrogen base having the properties of Vitamin B-6 is isolated and is freely soluble in water and sparingly in alcohol and acetone.
Effect of Heat Sterilization on Growth-Promoting Activity of Pyridoxine for Streptococcus lactis R
Results cited below show that the conversion results not from activities of the test organism, but rather from interaction of pyridoxine with certain constituents of the trast to those secured with all other known nutrilites which have been investigated.
Vitamin B2 and the Pellagra-like Dermatitis in Rats
The flavin pigment was identified by us with vitamin B2 by its growth-promoting properties and it was a question for further investigation whether in these circumstances it was also identical with the ‘anti-dermatitis factor’ and in particular with the 'pellagra preventing factor'.
Vitamin B6 and Skin Lesions in Rats
Vitamin B61 has been defined2 as “that part of the vitamin B2 complex which is responsible for the cure of the specific dermatitis developed by young rats fed on a vitamin B-free diet supplemented
Synthese des Adermins
En twick lungs s tufe de r europ~tischen Menschhe i t wird sich nach den bisher vor l iegenden F u n d e n wohl n i ch t e infach leugnen lassen.
The history of vitamin B
  • Am J Clin Nutr 1956;
  • 1956