A History of HIV Discovery

  title={A History of HIV Discovery},
  author={Luc Montagnier},
  pages={1727 - 1728}
It is almost 20 years since HIV was first isolated and identified as the cause of AIDS. This Viewpoint by Montagnier of the Pasteur Institute provides fresh insights into the frustrations and triumphs of the discovery of HIV, seen through the eyes of the French virologist whose team first identified this new human retrovirus. 
HIV and AIDS: 20 years of science
Some of the other important areas of accomplishment include the development of blood tests for HIV and increased knowledge of the molecular virology, epidemiology and pathogenesis of this virus.
The saga of the HIV controversy
Two scientists were honored recently with a Nobel Prize for the discovery of HIV. A third scientist was ignored. Over the past two decades, there has been a bitter controversy around the discovery of
Examining the discovery of the human retrovirus.
Retroviruses have been found in many bird and animal species where they often cause various types of cancer. Dr. Robert Gallo's contribution to the field of retrovirology and the link he established
Molecular biology of the human immunodeficiency virus: current and future targets for intervention.
  • P. Krogstad
  • Biology, Medicine
    Seminars in pediatric infectious diseases
  • 2003
This review presents an overview of HIV replication, emphasizing recently recognized cellular and viral molecules that may be exploited in future pharmacological approaches to prevent and treat infection with HIV.
HIV-1 integrase: from biology to chemotherapeutics.
This review focuses on the existing knowledge of the biology of HIV-1 IN with emphasis on the mechanism of integration, structure and function and the technologies for measuring IN activity, followed by the current trends on designing HIV- 1 IN inhibitors with the aid of molecular informatics.
The first postmodern pandemic: 25 years of HIV/ AIDS.
To meet the goal of universal access to prevention, treatment and care by 2010 would require a quadrupling of funding to an estimated US$42 billion by 2010, including adequate overall strengthening of healthcare systems, but in any case, the world will have to learn to live with HIV for the foreseeable future.
The HIV vaccine saga
This "Commentary" analyzes the reasons that the development of a vaccine has been so difficult, and proposes a plan to work towards an immunological approach to investigate the best vaccine candidates in the first world in individuals who are already infected.
A historical reflection on the discovery of human retroviruses
The discovery of HIV-1 as the cause of AIDS was one of the major scientific achievements during the last century. Here the events leading to this discovery are reviewed with particular attention to
Cytopathic Mechanisms of HIV-1
Information is gathered on TM in an attempt to shed some light on the functional regions of this protein, which is not well understood and is fiercely debated.


LAV revisited: origins of the early HIV-1 isolates from Institut Pasteur.
Two of the first human immunodeficiency virus type-1 (HIV-1) strains isolated were authenticated by reanalyzing original cultured samples stored at the Collection Nationale de Culture des
The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus
It is concluded that the CD4 antigen is an essential and specific component of the receptor for the causative agent of AIDS.
Isolation of a new human retrovirus from West African patients with AIDS.
It is established that this new retrovirus, here referred to as LAV-II, is distantly related to LAV and distinct from STLV-IIImac, suggesting that the West African AIDS virus may be more closely related to this simian virus than toLAV.
Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS).
From these studies it is concluded that this virus as well as the previous HTLV isolates belong to a general family of T-lymphotropic retroviruses that are horizontally transmitted in humans and may be involved in several pathological syndromes, including AIDS.
Isolation of lymphocytopathic retroviruses from San Francisco patients with AIDS.
Antibodies to ARV were found in all 86 AIDS patients and in a high percentage of 88 other homosexual men in San Francisco, indicating the widespread presence of these lymphocytopathic retroviruses and their close association with AIDS.
Major glycoprotein antigens that induce antibodies in AIDS patients are encoded by HTLV-III.
It is hypothesized that gp160 and gp120 represent the major species of virus-encoded envelope gene products for HTLV-III.
T-lymphocyte T4 molecule behaves as the receptor for human retrovirus  LAV
Preincubation of T4+ lymphocytes with three individual monoclonal antibodies directed at the T4 glycoprotein blocked cell infection by LAV, strongly support the view that a surface molecule directly involved in cellular functions acts as, or is related to, the receptor for a human retrovirus.
Infectious dna recovered from avian tumor‐virus‐producing cells
The amount of DNA required for successful infection varied widely between experiments, and the frequency of DNA‐treated cells which produced virus remained low, even when the assay cultures were pretreated with 5‐bromodeoxyuridine.