A High-Throughput Screening Strategy to Identify Inhibitors of SSB Protein-Protein Interactions in an Academic Screening Facility.

@article{Voter2018AHS,
  title={A High-Throughput Screening Strategy to Identify Inhibitors of SSB Protein-Protein Interactions in an Academic Screening Facility.},
  author={Andrew F Voter and Michael P. Killoran and Gene E. Ananiev and Scott A Wildman and Francis Michael Hoffmann and James L Keck},
  journal={SLAS discovery : advancing life sciences R & D},
  year={2018},
  volume={23 1},
  pages={94-101}
}
Antibiotic-resistant bacterial infections are increasingly prevalent worldwide, and there is an urgent need for novel classes of antibiotics capable of overcoming existing resistance mechanisms. One potential antibiotic target is the bacterial single-stranded DNA binding protein (SSB), which serves as a hub for DNA repair, recombination, and replication. Eight highly conserved residues at the C-terminus of SSB use direct protein-protein interactions (PPIs) to recruit more than a dozen important… CONTINUE READING
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