A High Through-Put Reverse Genetic Screen Identifies Two Genes Involved in Remote Memory in Mice

@article{Matynia2008AHT,
  title={A High Through-Put Reverse Genetic Screen Identifies Two Genes Involved in Remote Memory in Mice},
  author={Anna Matynia and Stephan G. Anagnostaras and Brian J. Wiltgen and Maress Lacuesta and Michael S Fanselow and Alcino J. Silva},
  journal={PLoS ONE},
  year={2008},
  volume={3},
  pages={119 - 130}
}
Previous studies have revealed that the initial stages of memory formation require several genes involved in synaptic, transcriptional and translational mechanisms. In contrast, very little is known about the molecular and cellular mechanisms underlying later stages of memory, including remote memory (i.e. 7-day memory). To identify genes required for remote memory, we screened randomly selected mouse strains harboring known mutations. In our primary reverse genetic screen, we identified 4… CONTINUE READING
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