A High Notch Pathway Activation Predicts Response to γ Secretase Inhibitors in Proneural Subtype of Glioma Tumor‐Initiating Cells

@article{Saito2014AHN,
  title={A High Notch Pathway Activation Predicts Response to γ Secretase Inhibitors in Proneural Subtype of Glioma Tumor‐Initiating Cells},
  author={Norihiko Saito and Jun Fu and S. Zheng and J. Yao and S. Wang and D. Liu and Y. Yuan and E. Sulman and F. Lang and H. Colman and R. G. Verhaak and W. Yung and D. Koul},
  journal={STEM CELLS},
  year={2014},
  volume={32}
}
  • Norihiko Saito, Jun Fu, +10 authors D. Koul
  • Published 2014
  • Biology, Medicine
  • STEM CELLS
  • Genomic, transcriptional, and proteomic analyses of brain tumors reveal subtypes that differ in pathway activity, progression, and response to therapy. However, a number of small molecule inhibitors under development vary in strength of subset and pathway‐specificity, with molecularly targeted experimental agents tending toward stronger specificity. The Notch signaling pathway is an evolutionarily conserved pathway that plays an important role in multiple cellular and developmental processes… CONTINUE READING
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