A High Affinity Glutamate/Aspartate Transport System in Pancreatic Islets of Langerhans Modulates Glucose-stimulated Insulin Secretion*

@article{Weaver1998AHA,
  title={A High Affinity Glutamate/Aspartate Transport System in Pancreatic Islets of Langerhans Modulates Glucose-stimulated Insulin Secretion*},
  author={C. David Weaver and Vidar Gundersen and Todd A. Verdoorn},
  journal={The Journal of Biological Chemistry},
  year={1998},
  volume={273},
  pages={1647 - 1653}
}
To examine the role of glutamatergic signaling in the function of pancreatic islets, we have characterized a high affinity glutamate/aspartate uptake system in this tissue. The islet [3H]glutamate uptake activity was Na+-dependent, and it was blocked byl-trans-pyrrolidine-2,4-dicarboxylic acid, a blocker of neuronal and glial glutamate transporters. Islet glutamate transport activity exhibited a V max of 8.48 ± 1.47 fmol/min/islet (n = 4), which corresponds to 102.2 ± 17.7 pmol/min/mg islet… 

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