A Hierarchy of Ankyrin/spectrin Complexes Clusters Sodium Channels at Nodes of Ranvier

The scaffolding protein ankyrin-G is required for Na+ channel clustering at axon initial segments. It is also considered essential for Na+ channel clustering at nodes of Ranvier to facilitate fast and efficient action potential propagation. However, notwithstanding these widely accepted roles, we show here that ankyrin-G is dispensable for nodal Na+ channel… CONTINUE READING