A Hierarchical Causal Taxonomy of Psychopathology Across the Life Span

@article{Lahey2017AHC,
  title={A Hierarchical Causal Taxonomy of Psychopathology Across the Life Span},
  author={Benjamin B. Lahey and Robert Frank Krueger and Paul J. Rathouz and Irwin D. Waldman and David H. Zald},
  journal={Psychological Bulletin},
  year={2017},
  volume={143},
  pages={142–186}
}
We propose a taxonomy of psychopathology based on patterns of shared causal influences identified in a review of multivariate behavior genetic studies that distinguish genetic and environmental influences that are either common to multiple dimensions of psychopathology or unique to each dimension. At the phenotypic level, first-order dimensions are defined by correlations among symptoms; correlations among first-order dimensions similarly define higher-order domains (e.g., internalizing or… 

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References

SHOWING 1-10 OF 555 REFERENCES
Higher-order genetic and environmental structure of prevalent forms of child and adolescent psychopathology.
TLDR
The best-fitting genetic model revealed that most genetic factors nonspecifically influence risk for either all 11 symptom dimensions or for dimensions of psychopathology within 1 of 2 broad domains, which implies that prevalent dimensions of child and adolescent psychopathology mostly share their genetic liabilities but are differentiated by nonshared experiences.
External validity of a hierarchical dimensional model of child and adolescent psychopathology: Tests using confirmatory factor analyses and multivariate behavior genetic analyses.
TLDR
It is found that both a General factor and specific Externalizing and Internalizing dimensions are necessary for characterizing youth psychopathology at both the phenotypic and etiologic levels, and that the 3 higher-order factors differed substantially in the magnitudes of their underlying genetic and environmental influences.
The structure of adolescent psychopathology: a symptom-level analysis
TLDR
This study is the first to identify a bifactor model including a specific thought disorder factor, and highlights the utility of transdiagnostic treatment approaches and the importance of restructuring psychopathology in an empirically based manner.
Modeling psychopathology structure: a symptom-level analysis of Axis I and II disorders
  • K. Markon
  • Psychology
    Psychological Medicine
  • 2009
TLDR
The results extend existing model frameworks ‘downward’ as well as ‘outward�’, by analyzing symptoms rather than diagnoses, and by integrating symptoms from Axis I and II disorders in a common framework.
Common genetic influences on negative emotionality and a general psychopathology factor in childhood and adolescence.
TLDR
Predictions based on the spectrum hypothesis were supported, with variance in negative emotionality and the general factor overlapping substantially at both phenotypic and etiologic levels.
Personality and psychopathology: genetic perspectives.
TLDR
It is illustrated how recent analytical advances in behavior genetics can use multivariate family data to address questions about the causal role of personality in psychopathology.
Annual research review: phenotypic and causal structure of conduct disorder in the broader context of prevalent forms of psychopathology.
  • B. Lahey, I. Waldman
  • Psychology, Medicine
    Journal of child psychology and psychiatry, and allied disciplines
  • 2012
BACKGROUND A better understanding of the nature and etiology of conduct disorder (CD) can inform nosology and vice versa. We posit that any prevalent form of psychopathology, including CD, can be
Posttraumatic stress disorder and the genetic structure of comorbidity.
TLDR
Examination of the phenotypic structure of these disorders revealed that PTSD cross-loaded on both Internalizing and Externalizing common factors, which have implications for conceptualizations of the etiology of PTSD and its location in an empirically based nosology.
Criterion validity of the general factor of psychopathology in a prospective study of girls.
TLDR
The hypothesis that the general factor of psychopathology in childhood is solely a measurement artifact is weakened and further research on the substantive meaning of the general factors is supported.
A population-based twin study of the relationship between neuroticism and internalizing disorders.
TLDR
There is substantial, but not complete, overlap between the genetic factors that influence individual variation in neuroticism and those that increase liability across the internalizing disorders, helping to explain the high rates of comorbidity among the latter.
...
1
2
3
4
5
...