A Heuristic method for assigning a false-discovery rate for protein identifications from Mascot database search results.

@article{Weatherly2005AHM,
  title={A Heuristic method for assigning a false-discovery rate for protein identifications from Mascot database search results.},
  author={D. Brent Weatherly and James A. Atwood and Todd Minning and Cameron Frank Cavola and Rick L. Tarleton and Ron Orlando},
  journal={Molecular & cellular proteomics : MCP},
  year={2005},
  volume={4 6},
  pages={
          762-72
        }
}
MS/MS and database searching has emerged as a valuable technology for rapidly analyzing protein expression, localization, and post-translational modifications. The probability-based search engine Mascot has found widespread use as a tool to correlate tandem mass spectra with peptides in a sequence database. Although the Mascot scoring algorithm provides a probability-based model for peptide identification, the independent peptide scores do not correlate with the significance of the proteins to… CONTINUE READING

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