A Helminth Immunomodulator Exploits Host Signaling Events to Regulate Cytokine Production in Macrophages

@inproceedings{Klotz2011AHI,
  title={A Helminth Immunomodulator Exploits Host Signaling Events to Regulate Cytokine Production in Macrophages},
  author={Christian Klotz and Thomas Ziegler and Ana Sofia Figueiredo and Sebastian Rausch and Matthew R Hepworth and Nadja Obsivac and Christine Sers and Roland Lang and Peter Hammerstein and Richard Lucius and Susanne Hartmann},
  booktitle={PLoS pathogens},
  year={2011}
}
Parasitic worms alter their host's immune system to diminish the inflammatory responses directed against them, using very efficient immunomodulating molecules. We have previously shown that the helminth immunomodulator cystatin (AvCystatin) profoundly reduces the progression of inflammatory diseases via modulation of macrophages. Here we elucidate the signaling events in macrophages triggered by AvCystatin. Labeled AvCystatin was predominantly taken up by macrophages and subsequently induced… CONTINUE READING
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