A Helix-Stabilizing Linker Improves Subcutaneous Bioavailability of a Helical Peptide Independent of Linker Lipophilicity.

@article{Zhang2016AHL,
  title={A Helix-Stabilizing Linker Improves Subcutaneous Bioavailability of a Helical Peptide Independent of Linker Lipophilicity.},
  author={Liang Zhang and Tejas Navaratna and Greg M Thurber},
  journal={Bioconjugate chemistry},
  year={2016},
  volume={27 7},
  pages={
          1663-72
        }
}
Stabilized peptides address several limitations to peptide-based imaging agents and therapeutics such as poor stability and low affinity due to conformational flexibility. There is also active research in developing these compounds for intracellular drug targeting, and significant efforts have been invested to determine the effects of helix stabilization on intracellular delivery. However, much less is known about the impact on other pharmacokinetic parameters such as plasma clearance and… CONTINUE READING

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