A Hard-Wired Glutamatergic Circuit Pools and Relays UV Signals to Mediate Spectral Preference in Drosophila

@article{Karuppudurai2014AHG,
  title={A Hard-Wired Glutamatergic Circuit Pools and Relays UV Signals to Mediate Spectral Preference in Drosophila},
  author={Thangavel Karuppudurai and Tzu-Yang Lin and Chun-Yuan Ting and Randall Pursley and Krishna V. Melnattur and Fengqiu Diao and Benjamin H White and Lindsey J. Macpherson and Marco Gallio and Thomas J Pohida and C Lee},
  journal={Neuron},
  year={2014},
  volume={81},
  pages={603-615}
}
UNLABELLED Many visual animals have innate preferences for particular wavelengths of light, which can be modified by learning. Drosophila's preference for UV over visible light requires UV-sensing R7 photoreceptors and specific wide-field amacrine neurons called Dm8. Here we identify three types of medulla projection neurons downstream of R7 and Dm8 and show that selectively inactivating one of them (Tm5c) abolishes UV preference. Using a modified GRASP method to probe synaptic connections at… CONTINUE READING