Corpus ID: 14562540

A Handbook of Mouse Models of Cardiovascular Disease

@inproceedings{Georges2009AHO,
  title={A Handbook of Mouse Models of Cardiovascular Disease},
  author={St George’s},
  year={2009}
}
The gentle and careful use of laboratory animals requires specific knowledge on the general biology and the characteristic hallmarks of the used animals and the adequate consideration of legal requirements, ethical aspects, and scientific guidelines. In this chapter, important topics of laboratory animal science regarding the mouse as laboratory animal are addressed. Initially, a brief historical overview of the mouse is given and the step from the house mouse to the worldwide actually mostly… Expand
Internet and Print Resources to Facilitate Pathology Analysis When Phenotyping Genetically Engineered Rodents
TLDR
This compilation provides an extensive register of materials related to the pathology component of rodent phenotypic analysis, and the authors annotate the resources they use most often to allow for quick determination of their relevance to research projects. Expand
Mouse model for myocardial injury caused by ischemia
TLDR
The mouse model for myocardial injury caused by ischemia has been created successfully by LAD ligation and the results showed that six weeks after narrowing the left coronary artery, the survival percentage of the experimental group was 77% and body weight and blood pressure of the Experimental group tended to decrease comparing to the control group. Expand
CD1d deficiency inhibits the development of abdominal aortic aneurysms in LDL receptor deficient mice
TLDR
It is proved that CD1d-dependent NKT cells contribute to AAA development in the Ang II-mediated aneurysm model by enhancing aortic degradation, establishing that therapeutic applications which target N KT cells can be a successful way to prevent AAA development. Expand
Reduced Levels of Testosterone Induce LDL Oxidation and Atherosclerotic Lesions Involving Inflammatory Imbalance and Reduced Macrophage Apoptosis
TLDR
The findings suggest that decreasing endogenous testosterone levels may induce the development of atherosclerosis, with participation of inflammatory response and macrophage apoptosis. Expand
Inflammation in injury-induced vascular remodelling : functional involvement and therapeutical options
TLDR
This thesis focused on inflammation in general, using the anti-inflammatory agent Dexamethasone, assessing the effects of such a broad approach on restenosis and vein graft remodeling and some specific parts of the immune system, namely Interleukin 10, chemokines and the complement cascade. Expand
The involvement of p38 gamma MAPK in pathological cardiac hypertrophy
TLDR
P38γ mitogen-activated protein kinase is a mediator of pathological cardiac hypertrophy and ablation of p38γ-MAPK reduces cardiac remodelling following pressure overload. Expand
Performance Comparison of Ultrasound-Based Methods to Assess Aortic Diameter and Stiffness in Normal and Aneurysmal Mice
TLDR
In small animal ultrasound the short axis view is preferred over the long axis view to measure aortic diameters, local methods are preferred over transit-time methods to measureAortic stiffness, invasive pressure-diameter data are preferredover non-invasive strains to measure local aorti stiffness, and the use of radiofrequency data improves the accuracy of diameter, strain as well as stiffness measurements. Expand
Erythropoietin Protects the Heart from Ventricular Arrhythmia during Ischemia and Reperfusion via Neuronal Nitric-Oxide Synthase
TLDR
It is concluded that EPO via nNOS protects the heart from spontaneous and CsCl-induced ventricular arrhythmia during myocardial I/R. Expand
Rapid clearance of Borrelia burgdorferi from the blood circulation
TLDR
A strict intravenous infection murine model is established using host-adapted spirochetes to draw the following conclusions: Bp survives in the blood and disseminates to the host’s brain via the hematogenous route; and Bbss, in contrast, is cleared rapidly from the blood stream and is a tissue-boundSpirochete. Expand
Inhibition of the intrinsic coagulation pathway factor XI by antisense oligonucleotides: a novel antithrombotic strategy with lowered bleeding risk.
TLDR
The concept that inhibition of FXI through antisense therapy might serve as a new and effective strategy for the treatment and prevention of venous thromboembolism with improved specificity and safety is supported. Expand
...
1
2
...

References

SHOWING 1-10 OF 68 REFERENCES
Mouse models of arteriosclerosis: from arterial injuries to vascular grafts.
  • Qingbo Xu
  • Medicine, Biology
  • The American journal of pathology
  • 2004
TLDR
This review will not attempt to cover all aspects of mouse models, rather focus on models of arterial injuries, vein grafts, and transplant arteriosclerosis, by which the major progress in understanding the mechanisms of the disease has been made. Expand
Principles of laboratory animal science : a contribution to the humane use and care of animals and to the quality of experimental results
TLDR
This chapter discusses the history of animal experimentation in the Netherlands, including its role in the domestication and husbandry of laboratory animals, and some of the aspects of animal welfare and ethics that have changed since then. Expand
Adverse effects of tribromoethanol as used in the production of transgenic mice
TLDR
Tribromoethanol caused focal to diffuse necrosis primarily of subperitoneal muscle fibres of the abdominal wall, and, occasionally, necrotic changes on the surface of abdominal organs, associated with acute peritoneal inflammation and fibrinous serositis of the abdomen organs. Expand
Inbred Strains in Biomedical Research
  • C. Potten
  • Medicine
  • British Journal of Cancer
  • 1981
TLDR
The book covers the broad range of biological studies of liver cells in culture, and the necessity for genetic quality control is considered, as also is the identification of terminal biliary ductular cells as facultative stem cells for liepatocytes. Expand
Effect of blood collection technique in mice on clinical pathology parameters.
TLDR
Evaluation of blood and serum samples in normal healthy C57BL/6 mice demonstrated the substantial impact that phlebotomy method has on the assay results and that the VC or IC methods provide the most consistent results. Expand
Mouse model of transplant arteriosclerosis: role of intercellular adhesion molecule-1.
TLDR
A simplified model of artery allografts in the mouse that allows us to take advantage of transgenic, knockout, or mutant animals is described and it is demonstrated that ICAM-1 is critical in the development of allografted arteriosclerosis via mediation of leukocyte adhesion to, and infiltration into, the vessel wall. Expand
Optimization of intraperitoneal injection anesthesia in mice: drugs, dosages, adverse effects, and anesthesia depth.
TLDR
The best intraperitoneal injection anesthesia regimen consisted of ketamine/xylazine/acepromazine, and the most reliable parameter of surgical tolerance under routine laboratory conditions was the pedal withdrawal reflex. Expand
Pharmacology of drugs used for anesthesia and sedation.
TLDR
The concepts underlying modern pharmacologic science, such as the study of pharmacokinetics, pharmodynamics, and drug interactions, are defined and the receptor mechanism mediating the actions of anesthetics and sedatives is reviewed. Expand
Genealogies of mouse inbred strains
TLDR
It is proposed that all genealogical and genetic data on inbred strains be submitted to a common electronic database to ensure this valuable information resource is preserved and used efficiently. Expand
Mouse model of venous bypass graft arteriosclerosis.
TLDR
A new model of vein grafts in the mouse is described, which reproduces many of the features of human vein graft arteriosclerosis and should prove useful for the understanding of the mechanism of veins graft disease and to evaluate the effects of drugs and gene therapy on vascular diseases. Expand
...
1
2
3
4
5
...