A HIF1α Regulatory Loop Links Hypoxia and Mitochondrial Signals in Pheochromocytomas

  title={A HIF1α Regulatory Loop Links Hypoxia and Mitochondrial Signals in Pheochromocytomas},
  author={Patricia L. M Dahia and Ken N. Ross and Matthew E Wright and Cesar Yoiti Hayashida and Sandro S. Santagata and Marta B. Barontini and Andrew L Kung and Gabriela E Sanso and James F. Powers and Arthur S. Tischler and Richard Aaron Hodin and Shannon M Heitritter and Francis D. Moore and Robert G. Dluhy and Julie Ann Sosa and Idris Tolgay Ocal and Diana E. Benn and Deborah J Marsh and Bruce Gregory Robinson and Katherine A. Schneider and Judy E Garber and Seth M. Arum and M{\'a}rta Korbonits and Ashley B. Grossman and Pascal Pigny and S{\'e}rgio Pereira de Almeida Toledo and Vania Nos{\'e} and Cheng Jiang Li and Charles Dean Stiles},
  journal={PLoS Genetics},
  pages={62 - 72}
Pheochromocytomas are neural crest-derived tumors that arise from inherited or sporadic mutations in at least six independent genes. The proteins encoded by these multiple genes regulate distinct functions. We show here a functional link between tumors with VHL mutations and those with disruption of the genes encoding for succinate dehydrogenase (SDH) subunits B (SDHB) and D (SDHD). A transcription profile of reduced oxidoreductase is detected in all three of these tumor types, together with an… CONTINUE READING
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