A HIF-1 target, ATIA, protects cells from apoptosis by modulating the mitochondrial thioredoxin, TRX2.

@article{Choksi2011AHT,
  title={A HIF-1 target, ATIA, protects cells from apoptosis by modulating the mitochondrial thioredoxin, TRX2.},
  author={Swati Choksi and Yong Lin and Yelena L Pobezinskaya and Li Yin Chen and Chung Park and Michael P. Morgan and Tiandao Li and Siriporn Jitkaew and Xiumei Cao and You-sun Kim and Hong-Sug Kim and Peter Levitt and Grace C. Shih and Michael Birre and Chu-Xia Deng and Zheng-gang Liu},
  journal={Molecular cell},
  year={2011},
  volume={42 5},
  pages={
          597-609
        }
}
The regulation of apoptosis is critical for controlling tissue homeostasis and preventing tumor formation and growth. Reactive oxygen species (ROS) generation plays a key role in such regulation. Here, we describe a HIF-1 target, Vasn/ATIA (anti-TNFα-induced apoptosis), which protects cells against TNFα- and hypoxia-induced apoptosis. Through the generation of ATIA knockout mice, we show that ATIA protects cells from apoptosis through regulating the function of the mitochondrial antioxidant… CONTINUE READING

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