A HER2/NEU-derived peptide, a K(d)-restricted murine tumor rejection antigen, induces HER2-specific HLA-A2402-restricted CD8(+) cytotoxic T lymphocytes.

@article{Ikuta2000AHP,
  title={A HER2/NEU-derived peptide, a K(d)-restricted murine tumor rejection antigen, induces HER2-specific HLA-A2402-restricted CD8(+) cytotoxic T lymphocytes.},
  author={Yasushi Ikuta and Toshiharu Okugawa and Reiko Furugen and Yoichi Nagata and Yoshiaki Takahashi and Lian Wang and Hitoshi Ikeda and Michiaki Watanabe and Shosuke Imai and Hiroshi Shiku},
  journal={International journal of cancer},
  year={2000},
  volume={87 4},
  pages={553-8}
}
We have identified an H-2K(d)-binding peptide, HER2p780 (PYVSRLLGI), derived from murine HER2/neu (HER2), that can induce HER2-specific murine cytotoxic T lymphocytes (CTL). Weekly vaccination of BALB/c mice by syngeneic dendritic cells pulsed with HER2p780 peptide, entirely common to murine and human HER2, suppressed growth of pretransplanted HER2-expressing syngeneic tumors. A HER2-expressing human cancer cell line SKOV3 transfected with murine H-2K(d) cDNA could also be lysed by HER2p780… CONTINUE READING

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