A H2S-Nampt Dependent Energetic Circuit Is Critical to Survival and Cytoprotection from Damage in Cancer Cells

@inproceedings{SanokawaAkakura2014AHD,
  title={A H2S-Nampt Dependent Energetic Circuit Is Critical to Survival and Cytoprotection from Damage in Cancer Cells},
  author={Reiko Sanokawa-Akakura and Elena A. Ostrakhovitch and Shin Akakura and Scott Goodwin and Siamak Tabibzadeh and Stefan Strack},
  booktitle={PloS one},
  year={2014}
}
We recently demonstrated that cancer cells that recover from damage exhibit increased aerobic glycolysis, however, the molecular mechanism by which cancer cells survive the damage and show increased aerobic glycolysis remains unknown. Here, we demonstrate that diverse cancer cells that survive hypoxic or oxidative damage show rapid cell proliferation, and develop tolerance to damage associated with increased production of hydrogen sulfide (H2S) which drives up-regulation of nicotinamide… CONTINUE READING
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