A H+-gated urea channel: the link between Helicobacter pylori urease and gastric colonization.

@article{Weeks2000AHU,
  title={A H+-gated urea channel: the link between Helicobacter pylori urease and gastric colonization.},
  author={David L. Weeks and Sepehr Eskandari and Dr. Robert I. Scott and George b. Sachs},
  journal={Science},
  year={2000},
  volume={287 5452},
  pages={
          482-5
        }
}
Acidic media trigger cytoplasmic urease activity of the unique human gastric pathogen Helicobacter pylori. Deletion of ureI prevents this activation of cytoplasmic urease that is essential for bacterial acid resistance. UreI is an inner membrane protein with six transmembrane segments as shown by in vitro transcription/translation and membrane separation. Expression of UreI in Xenopus oocytes results in acid-stimulated urea uptake, with a pH profile similar to activation of cytoplasmic urease… CONTINUE READING

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