A Graph-Based Semantic Similarity Measure for the gene Ontology

  title={A Graph-Based Semantic Similarity Measure for the gene Ontology},
  author={Marco A. Alvarez and Changhui Yan},
  journal={Journal of bioinformatics and computational biology},
  volume={9 6},
Existing methods for calculating semantic similarities between pairs of Gene Ontology (GO) terms and gene products often rely on external databases like Gene Ontology Annotation (GOA) that annotate gene products using the GO terms. This dependency leads to some limitations in real applications. Here, we present a semantic similarity algorithm (SSA), that relies exclusively on the GO. When calculating the semantic similarity between a pair of input GO terms, SSA takes into account the shortest… CONTINUE READING
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