A Granulin-Like Growth Factor Secreted by the Carcinogenic Liver Fluke, Opisthorchis viverrini, Promotes Proliferation of Host Cells

@inproceedings{Smout2009AGG,
  title={A Granulin-Like Growth Factor Secreted by the Carcinogenic Liver Fluke, Opisthorchis viverrini, Promotes Proliferation of Host Cells},
  author={Michael J Smout and Thewarach Laha and Jason P. Mulvenna and Banchob Sripa and Sutas Suttiprapa and Alun Jones and Paul J. Brindley and Alex Loukas},
  booktitle={PLoS pathogens},
  year={2009}
}
The human liver fluke, Opisthorchis viverrini, infects millions of people throughout south-east Asia and is a major cause of cholangiocarcinoma, or cancer of the bile ducts. The mechanisms by which chronic infection with O. viverrini results in cholangiocarcinogenesis are multi-factorial, but one such mechanism is the secretion of parasite proteins with mitogenic properties into the bile ducts, driving cell proliferation and creating a tumorigenic environment. Using a proteomic approach, we… CONTINUE READING
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