A Golgi localization signal identified in the Menkes recombinant protein.

@article{Francis1998AGL,
  title={A Golgi localization signal identified in the Menkes recombinant protein.},
  author={Michael James Francis and Evan E Jones and Elaine R. Levy and Sreenivasan Ponnambalam and Jamel Chelly and Anthony P Monaco},
  journal={Human molecular genetics},
  year={1998},
  volume={7 8},
  pages={1245-52}
}
Menkes disease arises from a genetic impairment in copper transport. The gene responsible for the phenotype has been identified as a copper transporting ATPase ( ATP7A ). Recently, the protein encoded by the ATP7A gene has been localized to the Golgi complex. In order to investigate the role of the Menkes disease protein in copper transport, recombinant constructs containing both the full-length open reading frame and an alternatively spliced form have been successfully expressed and localized… CONTINUE READING
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Functional expression of the Menkes disease protein reveals common biochemical mechanisms among the copper-transporting P-type ATPases

  • A. S. Payne, J. D. Gitlen
  • J. Biol. Chem.,
  • 1998

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