A Golgi-associated PDZ domain protein modulates cystic fibrosis transmembrane regulator plasma membrane expression.

@article{Cheng2002AGP,
  title={A Golgi-associated PDZ domain protein modulates cystic fibrosis transmembrane regulator plasma membrane expression.},
  author={Jie Cheng and Bryan D Moyer and Michal Milewski and Johannes Loffing and Masahiro Ikeda and John E. Mickle and Garry R. Cutting and Min Li and Bruce A. Stanton and William B Guggino},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 5},
  pages={
          3520-9
        }
}
We identified a novel cystic fibrosis transmembrane conductance regulator (CFTR)-associating, PDZ domain-containing protein, CAL (CFTR associated ligand) containing two predicted coiled-coiled domains and one PDZ domain. The PDZ domain of CAL binds to the C terminus of CFTR. Although CAL does not have any predicted transmembrane domains, CAL is associated with membranes mediated by a region containing the coiled-coil domains. CAL is located primarily at the Golgi apparatus, co-localizing with… CONTINUE READING
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