A Gly98Val Mutation in the N-Myc Downstream Regulated Gene 1 (NDRG1) in Alaskan Malamutes with Polyneuropathy

@inproceedings{Bruun2013AGM,
  title={A Gly98Val Mutation in the N-Myc Downstream Regulated Gene 1 (NDRG1) in Alaskan Malamutes with Polyneuropathy},
  author={Camilla Sichlau Bruun and Karin Hultin J{\"a}derlund and Mette Berendt and Kristine B. Jensen and Eva H. Spodsberg and Hanne Gredal and Gloria Diane Shelton and James R. Mickelson and Katie M. Minor and Hannes T Lohi and Inge Bjerk{\aa}s and \Oyvind Stigen and Arild Espenes and Cecilia Rohdin and Rebecca Edlund and J. Ingemar Ohlsson and Sigitas Cizinauskas and P{\'a}ll Sk{\'u}li Leifsson and Cord Dr{\"o}gem{\"u}ller and Lars Moe and Susanna Cirera and Merete Fredholm},
  booktitle={PloS one},
  year={2013}
}
The first cases of early-onset progressive polyneuropathy appeared in the Alaskan Malamute population in Norway in the late 1970s. Affected dogs were of both sexes and were ambulatory paraparetic, progressing to non-ambulatory tetraparesis. On neurologic examination, affected dogs displayed predominantly laryngeal paresis, decreased postural reactions, decreased spinal reflexes and muscle atrophy. The disease was considered eradicated through breeding programmes but recently new cases have… CONTINUE READING
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