A Global and Local Structure-Based Method for Predicting Binary Protein-Protein Interaction Partners: Proof of Principle and Feasibility

Abstract

We report a novel 3D structure-based method of predicting protein-protein (PP) interaction (PPI) partners. The method involves screening for pairs of tetrahedra representing interacting amino acids at the interface of the PP complex, with one tetrahedron on each protomer*. H-bonds and VDW interactions at the interface of the two interacting protein… (More)

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