A Global Perspective of Latent Autoimmune Diabetes in Adults

@article{Mishra2018AGP,
  title={A Global Perspective of Latent Autoimmune Diabetes in Adults},
  author={Rajashree Mishra and Kenyaita M. Hodge and Diana L. Cousminer and Richard David Leslie and Struan F. A. Grant},
  journal={Trends in Endocrinology \& Metabolism},
  year={2018},
  volume={29},
  pages={638-650}
}

Latent Autoimmune Diabetes in Adults: A Review on Clinical Implications and Management

Since the autoimmune process in LADA seems to be slower than in classical T1DM, there is a wider window for new therapeutic interventions that may slow down β-cell failure.

Latent Autoimmune Diabetes in Adults (LADA): From Immunopathogenesis to Immunotherapy

Light is shed on potential interventions targeting the gut microbiota and gut-associated immunity, which may be envisaged to halt or delay the process of autoimmunity in LADA, providing a wider window of opportunities for intervention.

A long and winding road to understand latent autoimmune diabetes in adults

The expanding understanding of LADA is discussed, an increasing number of researches worldwide have depicted and updated the naming, diagnostic criteria, clinical features, pathogenesis, and treatment of L ADA.

Etiology and Pathogenesis of Latent Autoimmune Diabetes in Adults (LADA) Compared to Type 2 Diabetes

Data from the limited number of studies on lifestyle factors available indicate that LADA may share several environmental risk factors with type 2 diabetes including overweight, physical inactivity, alcohol consumption (protective) and smoking, suggesting that onset of LADA, similar to type 1 diabetes, to some extent could be prevented or postponed by lifestyle modification such as weight reduction and increased physical activity.

Management of Latent Autoimmune Diabetes in Adults: A Consensus Statement From an International Expert Panel

The panel concluded by advising general screening for LADA in newly diagnosed non–insulin-requiring diabetes and, importantly, that large randomized clinical trials are warranted.

Latent autoimmune diabetes in adults in China

Comparing the similarities and differences between the Chinese and the Caucasian population from the perspectives of epidemiology, clinical, immunology and genetics will help to improve the understanding of LADA, and then promote LADA studies in individual populations.

A Case of Late Diagnosis of Latent Autoimmune Diabetes in Adults

A 71-year-old man diagnosed with type 2 diabetes two years ago, poorly controlled with oral antidiabetic therapy, and worsening in the third year is reported, highlighting the importance of being aware of this disease, especially in patients previously diagnosed withtype 2 diabetes who remain uncontrolled with diet and oral hypoglycemic agents.

Therapeutic approaches for latent autoimmune diabetes in adults: One size does not fit all

The aim of the present review is to discuss the current state and future perspectives of LADA therapy, emphasizing the need for individualized and patient‐centered therapeutic approaches.

Type 1 diabetes mellitus: much progress, many opportunities.

  • A. Powers
  • Medicine, Biology
    The Journal of clinical investigation
  • 2021
It is now clear that there is considerable heterogeneity in T1D with regards to genetics, pathology, response to immune-based therapies, clinical course, and susceptibility to diabetes-related complications.

Latent Autoimmune Diabetes in Adults (LADA) in Recent Clinical Practice

  • H. Bando
  • Medicine
    Diabetes Research – Open Journal
  • 2019
There are some types of diabetes, in which the prevalence of type 2 diabetes mellitus has been higher without requiring insulin treatment, and there is a disease that has been clinically important in recent years, it is Latent autoimmune diabetes in adults (LADA).

References

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Adult-Onset Autoimmune Diabetes in Europe Is Prevalent With a Broad Clinical Phenotype

The results indicate that adult-onset autoimmune diabetes in Europe encompasses type 1 diabetes and LADA in the same broad clinical and autoantibody-positive spectrum.

Heterogeneity of Patients With Latent Autoimmune Diabetes in Adults: Linkage to Autoimmunity Is Apparent Only in Those With Perceived Need for Insulin Treatment

The need for insulin treatment in LADA is linked to the degree of autoimmunity and β-cell failure,Subjects with the diagnosis of latent autoimmune diabetes in adults (LADA) are more prone to need insulin treatment than those with type 2 diabetes, but not all patients with LADA develop the need forulin treatment, indicating the heterogeneity of LADA.

The prevalence and characteristics of latent autoimmune diabetes in adults subset among type two diabetes mellitus patients in Northern Nigeria

The prevalence of LADA among T2DM patients in Northern Nigeria is found to be 10.5%.

Adult-onset autoimmune diabetes: current knowledge and implications for management

The current understanding and gaps in knowledge regarding the pathophysiology and clinical features of adult-onset autoimmune diabetes are discussed and the similarities and differences with classic T1DM and type 2 diabetes mellitus are highlighted.

High Titer of Autoantibodies to GAD Identifies a Specific Phenotype of Adult-Onset Autoimmune Diabetes

GADA titers identify two subgroups of patients with adult-onset autoimmune diabetes having distinct clinical, autoimmune, and genetic features.

Latent Autoimmune Diabetes in Adults in the United Arab Emirates: Clinical Features and Factors Related to Insulin-Requirement

It is shown that the clinical phenotype of LADA is dependent on different patterns of antibody positivity, influencing the time to insulin requirement, which appears to be different from both type 1 and type 2 diabetes.

Latent Autoimmune Diabetes Mellitus in Adults (LADA) and it’s characteristics in a subset of Nigerians initially managed for type 2 diabetes

The diagnosis of LADA should be entertained in overweight/obese persons from the fourth decade of life presenting with DM especially since a significant proportion are insulinopaenic and Pharmacotherapy with insulin is a potential means of managing hyperglycaemia in this group of patients.

IA‐2 Autoantibodies Are Predominant in Latent Autoimmune Diabetes in Adults Patients from Eastern India

The data suggest that LADA is more frequent in Eastern Indian T2DM patients and the IA‐2 is the predominant autoantibody in this population.

Frequency, Immunogenetics, and Clinical Characteristics of Latent Autoimmune Diabetes in China (LADA China Study)

This study implicates universal immunogenetic effects, with some ethnic differences, in adult-onset autoimmune diabetes, and suggests autoantibody positivity and titer could be important for LADA risk stratification and accurate therapeutic choice in clinical practice.
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