A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells

  title={A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells},
  author={Micah J. Niphakis and Kenneth M. Lum and Armand B Cognetta and Bruno E. Correia and Taka-Aki Ichu and Jose Olucha and Steven J. Brown and Soumajit Kundu and Fabiana Piscitelli and H. K. Rosen and Benjamin F Cravatt},
Lipids play central roles in physiology and disease, where their structural, metabolic, and signaling functions often arise from interactions with proteins. Here, we describe a set of lipid-based chemical proteomic probes and their global interaction map in mammalian cells. These interactions involve hundreds of proteins from diverse functional classes and frequently occur at sites of drug action. We determine the target profiles for several drugs across the lipid-interaction proteome… CONTINUE READING
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