A Glanzmann's mutation in beta 3 integrin specifically impairs osteoclast function.

@article{Feng2001AGM,
  title={A Glanzmann's mutation in beta 3 integrin specifically impairs osteoclast function.},
  author={Xu Feng and Deborah V Novack and Roberta Faccio and Daniel S Ory and Kunihiko Aya and Martin Israel Boyer and Kevin P. Mchugh and Frederick Ross and Steven L Teitelbaum},
  journal={The Journal of clinical investigation},
  year={2001},
  volume={107 9},
  pages={1137-44}
}
Osteoclastic bone resorption requires cell-matrix contact, an event mediated by the alpha v beta 3 integrin. The structural components of the integrin that mediate osteoclast function are, however, not in hand. To address this issue, we generated mice lacking the beta 3 integrin gene, which have dysfunctional osteoclasts. Here, we show the full rescue of beta 3(-/-) osteoclast function following expression of a full-length beta 3 integrin. In contrast, truncated beta 3, lacking a cytoplasmic… CONTINUE READING

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