A Gibbs sampler for identification of symmetrically structured, spaced DNA motifs with improved estimation of the signal length

@article{Favorov2005AGS,
  title={A Gibbs sampler for identification of symmetrically structured, spaced DNA motifs with improved estimation of the signal length},
  author={Alexander V. Favorov and Mikhail S. Gelfand and Anna V. Gerasimova and Dmitry A. Ravcheev and Andrey A. Mironov and Vsevolod J. Makeev},
  journal={Bioinformatics},
  year={2005},
  volume={21 10},
  pages={2240-5}
}
MOTIVATION Transcription regulatory protein factors often bind DNA as homo-dimers or hetero-dimers. Thus they recognize structured DNA motifs that are inverted or direct repeats or spaced motif pairs. However, these motifs are often difficult to identify owing to their high divergence. The motif structure included explicitly into the motif recognition algorithm improves recognition efficiency for highly divergent motifs as well as estimation of motif geometric parameters. RESULT We present a… CONTINUE READING
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