A Germline Polymorphism of DNA Polymerase Beta Induces Genomic Instability and Cellular Transformation

@inproceedings{Yamtich2012AGP,
  title={A Germline Polymorphism of DNA Polymerase Beta Induces Genomic Instability and Cellular Transformation},
  author={Jennifer Yamtich and Antonia A. Nemec and Agnes Keh and Joann Balazs Sweasy},
  booktitle={PLoS genetics},
  year={2012}
}
Several germline single nucleotide polymorphisms (SNPs) have been identified in the POLB gene, but little is known about their cellular and biochemical impact. DNA Polymerase β (Pol β), encoded by the POLB gene, is the main gap-filling polymerase involved in base excision repair (BER), a pathway that protects the genome from the consequences of oxidative DNA damage. In this study we tested the hypothesis that expression of the POLB germline coding SNP (rs3136797) in mammalian cells could induce… CONTINUE READING
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Loop II of DNA polymerase beta is important for polymerization activity and fidelity

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  • Nucleic Acids Res
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