A Genomic Pathway Approach to a Complex Disease: Axon Guidance and Parkinson Disease

@article{Lesnick2007AGP,
  title={A Genomic Pathway Approach to a Complex Disease: Axon Guidance and Parkinson Disease},
  author={Timothy G. Lesnick and Spyridon Spyros Papapetropoulos and Deborah C. Mash and Jarlath ffrench-Mullen and Lina A. Shehadeh and Mariza de Andrade and John R. Henley and Walter A. Rocca and J. Eric Ahlskog and Demetrius M. Maraganore},
  journal={PLoS Genetics},
  year={2007},
  volume={3},
  pages={2037 - 2048}
}
While major inroads have been made in identifying the genetic causes of rare Mendelian disorders, little progress has been made in the discovery of common gene variations that predispose to complex diseases. The single gene variants that have been shown to associate reproducibly with complex diseases typically have small effect sizes or attributable risks. However, the joint actions of common gene variants within pathways may play a major role in predisposing to complex diseases (the paradigm… CONTINUE READING

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