A Genomic-Based Approach Combining In Vivo Selection in Mice to Identify a Novel Virulence Gene in Leishmania

@article{Zhang2008AGA,
  title={A Genomic-Based Approach Combining In Vivo Selection in Mice to Identify a Novel Virulence Gene in Leishmania},
  author={Wen-wei Zhang and Christopher Sean Peacock and G. J. Matlashewski},
  journal={PLoS Neglected Tropical Diseases},
  year={2008},
  volume={2},
  pages={1191 - 1199}
}
BACKGROUND Infection with Leishmania results in a broad spectrum of pathologies where L. infantum and L. donovani cause fatal visceral leishmaniasis and L. major causes destructive cutaneous lesions. The identification and characterization of Leishmania virulence genes may define the genetic basis for these different pathologies. METHODS AND FINDINGS Comparison of the recently completed L. major and L. infantum genomes revealed a relatively small number of genes that are absent or present as… CONTINUE READING

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