A Genome-wide Multidimensional RNAi Screen Reveals Pathways Controlling MHC Class II Antigen Presentation

@article{Paul2011AGM,
  title={A Genome-wide Multidimensional RNAi Screen Reveals Pathways Controlling MHC Class II Antigen Presentation},
  author={Petra Paul and Tineke van den Hoorn and Marlieke L.M. Jongsma and Mark Bakker and Rutger C. C. Hengeveld and Lennert J Janssen and Peter Cresswell and David A. Egan and Marieke H.A. van Ham and Anja ten Brinke and Huib Ovaa and Roderick Leonardus Beijersbergen and Coenraad P. Kuijl and Jacques Neefjes},
  journal={Cell},
  year={2011},
  volume={145},
  pages={268-283}
}
MHC class II molecules (MHC-II) present peptides to T helper cells to facilitate immune responses and are strongly linked to autoimmune diseases. To unravel processes controlling MHC-II antigen presentation, we performed a genome-wide flow cytometry-based RNAi screen detecting MHC-II expression and peptide loading followed by additional high-throughput assays. All data sets were integrated to answer two fundamental questions: what regulates tissue-specific MHC-II transcription, and what… CONTINUE READING
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