A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity

@inproceedings{Cao2019AGH,
  title={A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity},
  author={Jennifer Yinuo Cao and Aunoy Poddar and Leslie Magtanong and Jennifer H. Lumb and Trevor R. Mileur and Michael J. A. Reid and Cole Mackaman Dovey and Jin Wang and Jason W. Locasale and Everett Stone and Susan P. C. Cole and Jan Eduard Carette and Scott J. Dixon},
  booktitle={Cell reports},
  year={2019}
}
The tripeptide glutathione suppresses the iron-dependent, non-apoptotic cell death process of ferroptosis. How glutathione abundance is regulated in the cell and how this regulation alters ferroptosis sensitivity is poorly understood. Using genome-wide human haploid genetic screening technology coupled to fluorescence-activated cell sorting (FACS), we directly identify genes that regulate intracellular glutathione abundance and characterize their role in ferroptosis regulation. Disruption of… CONTINUE READING
BETA
8
Twitter Mentions