A Genome-wide Association Study Identifies Risk Alleles in Plasminogen and P4HA2 Associated with Giant Cell Arteritis.

@article{Carmona2017AGA,
  title={A Genome-wide Association Study Identifies Risk Alleles in Plasminogen and P4HA2 Associated with Giant Cell Arteritis.},
  author={F. David Carmona and Augusto Vaglio and Sarah Louise Mackie and Jos{\'e} Hern{\'a}ndez-Rodr{\'i}guez and Paul Monach and Santos Casta{\~n}eda and Roser Solans and Inmaculada C. Morado and Javier Narv{\'a}ez and Marc Ramentol-Sintas and Colin Thomas Pease and Bhaskar Dasgupta and Richard A Watts and Nader Khalidi and Carol A Langford and Steven Ytterberg and Luigi Boiardi and Lorenzo Beretta and Marcello Govoni and Giacomo Emmi and Francesco Bonatti and Marco Amedeo Cimmino and Torsten Witte and Thomas Neumann and Julia Ulrike Holle and Verena Schoenau and Laurent J Sailler and Thomas Papo and Julien Haroche and Alfred Mahr and Luc Mouthon and \Oyvind Molberg and Andreas P. Diamantopoulos and Alexandre E. Voskuyl and Elisabeth Cath{\'e}rine Brouwer and Thomas D Daikeler and Christoph T Berger and Eamonn S. Molloy and Lorraine O'Neill and Daniel Blockmans and Benedicte Alexandra Lie and Paul J. McLaren and Timothy J Vyse and Cisca Wijmenga and Yannick Allanore and Bobby P. C. Koeleman and Jennifer H. Barrett and Maria C Cid and Carlo Salvarani and Peter A. Merkel and Ann W Morgan and Miguel A Gonz{\'a}lez-Gay and Javier Martin},
  journal={American journal of human genetics},
  year={2017},
  volume={100 1},
  pages={64-74}
}
Giant cell arteritis (GCA) is the most common form of vasculitis in individuals older than 50 years in Western countries. To shed light onto the genetic background influencing susceptibility for GCA, we performed a genome-wide association screening in a well-powered study cohort. After imputation, 1,844,133 genetic variants were analyzed in 2,134 case… CONTINUE READING