A Genome-Wide siRNA Screen Implicates Spire1/2 in SipA-Driven Salmonella Typhimurium Host Cell Invasion

@inproceedings{Andritschke2016AGS,
  title={A Genome-Wide siRNA Screen Implicates Spire1/2 in SipA-Driven Salmonella Typhimurium Host Cell Invasion},
  author={Daniel Andritschke and Sabrina Dilling and Mario Emmenlauer and Tobias Welz and Fabian Schmich and Benjamin Misselwitz and Pauli R{\"a}m{\"o} and Klemens Rottner and Eugen Kerkhoff and Teiji Wada and Josef M Penninger and Niko Beerenwinkel and P{\'e}ter Horv{\'a}th and Christoph Dehio and Wolf-Dietrich Hardt},
  booktitle={PloS one},
  year={2016}
}
Salmonella Typhimurium (S. Tm) is a leading cause of diarrhea. The disease is triggered by pathogen invasion into the gut epithelium. Invasion is attributed to the SPI-1 type 3 secretion system (T1). T1 injects effector proteins into epithelial cells and thereby elicits rearrangements of the host cellular actin cytoskeleton and pathogen invasion. The T1 effector proteins SopE, SopB, SopE2 and SipA are contributing to this. However, the host cell factors contributing to invasion are still not… CONTINUE READING

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