A Genome-Wide Screen for Promoter Methylation in Lung Cancer Identifies Novel Methylation Markers for Multiple Malignancies

@article{Shames2006AGS,
  title={A Genome-Wide Screen for Promoter Methylation in Lung Cancer Identifies Novel Methylation Markers for Multiple Malignancies },
  author={David S. Shames and Luc Girard and Boning Gao and Mitsuo Sato and Cheryl M. Lewis and Narayan Shivapurkar and Aixiang Jiang and Charles M. Perou and Young Hee Kim and Jonathan R. Pollack and Kwun Meng Fong and C. Y. Teresa Lam and Maria Pik Wong and Yu Shyr and Rita Nanda and Olufunmilayo I. Olopade and William L. Gerald and David Michael Euhus and Jerry W Shay and Adi F. Gazdar and John D. Minna},
  journal={PLoS Medicine},
  year={2006},
  volume={3},
  pages={615 - 625}
}
BACKGROUND Promoter hypermethylation coupled with loss of heterozygosity at the same locus results in loss of gene function in many tumor cells. The "rules" governing which genes are methylated during the pathogenesis of individual cancers, how specific methylation profiles are initially established, or what determines tumor type-specific methylation are unknown. However, DNA methylation markers that are highly specific and sensitive for common tumors would be useful for the early detection of… CONTINUE READING
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