A Genome-Wide Screen for Promoter Methylation in Lung Cancer Identifies Novel Methylation Markers for Multiple Malignancies

  title={A Genome-Wide Screen for Promoter Methylation in Lung Cancer Identifies Novel Methylation Markers for Multiple Malignancies},
  author={D. Shames and L. Girard and B. Gao and M. Sato and C. Lewis and N. Shivapurkar and A. Jiang and C. Perou and Y. Kim and J. Pollack and K. Fong and C. Lam and M. Wong and Y. Shyr and R. Nanda and O. Olopade and W. Gerald and D. Euhus and J. Shay and A. Gazdar and J. Minna},
  journal={PLoS Medicine},
  • D. Shames, L. Girard, +18 authors J. Minna
  • Published 2006
  • Biology, Medicine
  • PLoS Medicine
  • Background Promoter hypermethylation coupled with loss of heterozygosity at the same locus results in loss of gene function in many tumor cells. The “rules” governing which genes are methylated during the pathogenesis of individual cancers, how specific methylation profiles are initially established, or what determines tumor type-specific methylation are unknown. However, DNA methylation markers that are highly specific and sensitive for common tumors would be useful for the early detection of… CONTINUE READING
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