A Genome-Wide Screen for Promoter Methylation in Lung Cancer Identifies Novel Methylation Markers for Multiple Malignancies

@article{Shames2006AGS,
  title={A Genome-Wide Screen for Promoter Methylation in Lung Cancer Identifies Novel Methylation Markers for Multiple Malignancies},
  author={D. Shames and L. Girard and B. Gao and M. Sato and C. Lewis and N. Shivapurkar and A. Jiang and C. Perou and Y. Kim and J. Pollack and K. Fong and C. Lam and M. Wong and Y. Shyr and R. Nanda and O. Olopade and W. Gerald and D. Euhus and J. Shay and A. Gazdar and J. Minna},
  journal={PLoS Medicine},
  year={2006},
  volume={3}
}
  • D. Shames, L. Girard, +18 authors J. Minna
  • Published 2006
  • Biology, Medicine
  • PLoS Medicine
  • Background Promoter hypermethylation coupled with loss of heterozygosity at the same locus results in loss of gene function in many tumor cells. The “rules” governing which genes are methylated during the pathogenesis of individual cancers, how specific methylation profiles are initially established, or what determines tumor type-specific methylation are unknown. However, DNA methylation markers that are highly specific and sensitive for common tumors would be useful for the early detection of… CONTINUE READING
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    References

    SHOWING 1-10 OF 70 REFERENCES
    Application of a methylation gene panel by quantitative PCR for lung cancers.
    • 91
    A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer
    • 853
    A systematic profile of DNA methylation in human cancer cell lines.
    • 354
    • PDF
    DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis.
    • 436
    • PDF
    Aberrant promoter methylation of multiple genes in non-small cell lung cancers.
    • 615
    • PDF
    A gene hypermethylation profile of human cancer.
    • 2,066
    Aberrant promoter methylation of multiple genes during multistep pathogenesis of colorectal cancers
    • 46
    A Quantitative Promoter Methylation Profile of Prostate Cancer
    • 254
    • PDF
    Evidence for an instructive mechanism of de novo methylation in cancer cells
    • 473
    • PDF
    Discovery of novel targets for aberrant methylation in pancreatic carcinoma using high-throughput microarrays.
    • 310
    • Highly Influential
    • PDF